Alpha-Mannosidosis Market to Exhibit Moderate Growth Rate till 2032, Estimates DelveInsight | Key Companies – Chiesi Farmaceutici (velmanase alfa), Smart Pharm Therapeutics

September 20 20:34 2022
Alpha-Mannosidosis Market to Exhibit Moderate Growth Rate till 2032, Estimates DelveInsight | Key Companies - Chiesi Farmaceutici (velmanase alfa), Smart Pharm Therapeutics
Delveinsight Business Research LLP
As per DelveInsight, the Alpha-Mannosidosis therapeutics market is expected to grow in the coming years owing to the expected increasing awareness and rising eligible population of Alpha-Mannosidosis in the 7MM.

DelveInsight’s “Alpha-Mannosidosis Market Insights, Epidemiology, and Market Forecast 2032” report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Alpha-Mannosidosis Market size, share, and trends in the seven major market (7MM) (i.e., the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan).

The Alpha-Mannosidosis market report covers emerging drugs, current treatment practices, market share of the individual therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current treatment practice/algorithm, key drivers & barriers impacting the market growth, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market. 

Alpha-Mannosidosis Market

Alpha-Mannosidosis: An Overview

Alpha-mannosidosis (α-mannosidosis) is a rare lysosomal storage disorder with an autosomal recessive inheritance caused by mutations in the gene encoding for the lysosomal α-D-mannosidas.

It is caused by the lack of the lysosomal enzyme-alpha-mannosidase due to a mutation in MAN2B1, located on chromosome 19, that causes disturbed glycoprotein catabolism leading to an excessively high level of mannose-rich oligosaccharides in many tissues. This accumulation in various cells leads to various complications in patients.

Alpha-mannosidosis is inherited in an autosoma recessive manner and is reported to affect 1 in 1,000,000 people worldwide. At conception, each sibling of an affected individual has a 25% chance of being affected 50% chance of being an asymptomatic carrier. 

Alpha-Mannosidosis Market Key Facts

• As per NORD, Alpha-Mannosidosis is an ultra-rare progressive disorder that occurs in approximately 1 of 500,000 live births. Children are often born apparently normal, and their condition worsens progressively. Some children are born with ankle equinus or develop hydrocephalus in the first year of life (Malm et al.).

• According to the Systematic Review of the Epidemiology of α-mannosidosis in 2017, the overall incidence of the disease globally ranges from 0.07 to 1.51 per 100,000 births. (Finocchiaro et al.)

Alpha-Mannosidosis Market

The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted Alpha-Mannosidosis market size by analyzing the impact of current and emerging pipeline therapies. It also provides a thorough assessment of the market drivers & barriers, unmet needs, and emerging technologies set to impact the market dynamics.

The report gives complete detail of the Alpha-Mannosidosis market trend for each marketed drug and mid & late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, their Mechanism of Action (MoA), Route of Administration (RoA), molecule types, competition with other therapies, brand value, and their impact on the market.

Alpha-Mannosidosis Epidemiology

The epidemiology section provides insights into the historical, current, and forecasted epidemiology trends in the seven major countries (7MM) from 2019 to 2032. It helps to recognize the causes of current and forecasted epidemiology trends by exploring numerous studies and research. The epidemiology section also provides a detailed analysis of diagnosed and prevalent patient pool, future trends, and and views of key opinion leaders. 

Alpha-Mannosidosis Epidemiology Segmentation

• Prevalent cases of Alpha-Mannosidosis

• Severity-specific cases of Alpha-Mannosidosis

• Diagnosed and Treatable Cases of Alpha-Mannosidosis

Alpha-Mannosidosis Drugs Uptake and Pipeline Development Activities

The drugs uptake section focuses on the rate of uptake of the potential drugs recently launched in the Alpha-Mannosidosis market or expected to get launched during the study period. The analysis covers Alpha-Mannosidosis market uptake by drugs, patient uptake by therapies, and sales of each drug. 

Moreover, the therapeutics assessment section helps understand the drugs with the most rapid uptake and the reasons behind the maximal use of the drugs. Additionally, it compares the drugs based on market share.

The report also covers the Alpha-Mannosidosis Pipeline Development Activities. It provides valuable insights about different therapeutic candidates in various stages and the key companies involved in developing targeted therapeutics. It also analyses recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

Recent Developments in the Alpha-Mannosidosis Therapeutics Market

Enzyme replacement therapy is the standard therapy for a number of inherited diseases for treating lysosomal storage diseases. New treatment approvals in this rare space have boosted the R&D. Even though limited companies are working in this space, the segment is expected to register moderate growth in the coming years.

• • On Sept. 12, 2022, Chiesi Global Rare Diseases announced that the US FDA accepted the Biologics License Application (BLA) and granted Priority Review designation for velmanase alfa. FDA grants Priority Review designation with PDUFA date in the first half of 2023. velmanase alfa is Chiesi’s investigational enzyme replacement therapy for the proposed treatment of ultra-rare disease alpha-mannosidosis.

Learn how Alpha-Mannosidosis Market will evolve with the ongoing clinical and commercial development activities in the Alpha-Mannosidosis Therapeutics Market by 2032 @

Alpha-Mannosidosis Therapeutics Analysis

Treatment of alpha-mannosidosis is symptomatic and supportive. Therapy is directed at preventing and treating the complications of the disorder. Thus, it is important to be proactive. Alpha-Mannosidosis treatment options include bone marrow transplant or peripheral blood stem cell transplantation. Additionally, Enzyme replacement therapy may be used as a treatment option.

Globally, a few key companies are actively working in the Alpha-Mannosidosis therapeutics market to improve treatment scenarios.

Key companies in the Alpha-Mannosidosis Therapeutics Market include

• Smart Pharm Therapeutics

• Chiesi Farmaceutici

And other institutes

Further Emerging Drugs & Key Companies are Covered in the Report. Download the Sample PDF to Learn More –

Table of Content (TOC)

1. Key Insights

2. Executive Summary 

3. Alpha-Mannosidosis Competitive Intelligence Analysis

4. Alpha-Mannosidosis Market Overview at a Glance

5. Alpha-Mannosidosis Disease Background and Overview

6. Alpha-Mannosidosis Patient Journey

7. Alpha-Mannosidosis Epidemiology and Patient Population (In US, EU5, and Japan)

8. Alpha-Mannosidosis Treatment Algorithm, Current Treatment, and Medical Practices

9. Alpha-Mannosidosis Unmet Needs

10. Key Endpoints of Alpha-Mannosidosis Treatment

11. Alpha-Mannosidosis Marketed Products

12. Alpha-Mannosidosis Emerging Drugs and Latest Therapeutic Advances

13. Alpha-Mannosidosis Seven Major Market Analysis

14. Attribute Analysis

15. Alpha-Mannosidosis Market Outlook (In US, EU5, and Japan)

16. Alpha-Mannosidosis Access and Reimbursement Overview

17. KOL Views on the Alpha-Mannosidosis Market

18. Alpha-Mannosidosis Market Drivers

19. Alpha-Mannosidosis Market Barriers

20. Appendix

21. DelveInsight Capabilities

22. Disclaimer

*The Table of Contents (TOC) is not exhaustive; the final content may vary. Refer to the sample report for the complete table of contents.

Download Sample PDF to Explore the Key Offerings of the Report:


About DelveInsight
DelveInsight is a leading Business Consultant and Market Research Firm focused exclusively on life sciences. It supports pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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