United States, Nevada, Las Vegas, DelveInsight’s ‘Septic Shock Pipeline Insight 2023‘ report provides comprehensive global coverage of available, marketed, and pipeline Septic Shock therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Septic Shock pipeline domain.
Key Takeaways from the Septic Shock Pipeline Report
Septic Shock Overview
Sepsis syndromes span a clinical continuum with variable prognoses. Septic shock, the most severe complication of sepsis, carries a high mortality. Septic shock occurs in response to an inciting agent, which causes both pro-inflammatory and anti-inflammatory immune system activation. This occurs in concert with the activation of monocytes, macrophages, and neutrophils that interact with the endothelium through pathogen recognition receptors and lead to further involvement of cytokines, proteases, kinins, reactive oxygen species, and nitric oxide. As the primary site of this response, the endothelium not only suffers microvascular injury but also activates the coagulation and complement cascades, further exacerbating the vascular injury, leading to capillary leakage. This cascade of events is responsible for sepsis’s clinical signs and symptoms and progression from sepsis to septic shock. Striking a balance between pro-inflammatory responses, which help eradicate the invading microorganism, and anti-inflammatory signals, which keep the inflammatory cascade in check, ultimately determines the degree of morbidity and/or mortality of patients with sepsis. Judicious and early antimicrobial administration, sepsis care bundle use, and early goal-directed therapies have significantly and positively impacted sepsis-related mortality. However, early identification remains the best therapeutic tool for sepsis treatment and management. This activity describes the evaluation and management of septic shock and highlights the role of the interprofessional team in enhancing care delivery for affected patients.
Septic Shock Pipeline Analysis: Drug Profile
Adrecizumab: Adrenomed
Adrecizumab is a proprietary humanized monoclonal adrenomedullin (ADM) specific antibody. This targeted therapy inhibits excessive circulating sepsis-induced ADM, stimulates protective effects on the endothelial barrier, and decreases interstitial vasodilatory effects. Currently, it is in Phase II stage of clinical trial evaluation to treat septic shock.
Discover more about the emerging Septic Shock drugs @ Septic Shock Treatment Drugs
Septic Shock Key Companies
Septic Shock Pipeline Therapies
Septic Shock Pipeline Therapeutics Assessment
Scope of the Septic Shock Pipeline Report
Find out more about the Septic Shock treatment options in development @ Septic Shock Clinical Trials
Table of Contents
1. Introduction
2. Executive Summary
3. Overview
4. Pipeline Therapeutics
5. Late-Stage Products (Phase III)
6. Mid-Stage Products (Phase II)
7. Early Stage Products (Phase I/II)
8. Preclinical Stage Products
9. Discovery Stage Products
10. Therapeutic Assessment
11. Inactive Products
12. Collaborations Assessment- Licensing / Partnering / Funding
13. Unmet Needs
14. Market Drivers and Barriers
15. Appendix
16. About DelveInsight
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