Von Willebrand Disease Pipeline constitutes 3 + key companies continuously working towards developing 3+ Von Willebrand Disease treatment therapies, analyzes DelveInsight.
Von Willebrand Disease Overview:
Von Willebrand disease (VWD) is the most prevalent inherited bleeding disorder, resulting from a deficiency or malfunction of von Willebrand factor (VWF), a protein crucial for proper blood clotting. This disorder impairs platelet adhesion to blood vessel walls, leading to unusual or prolonged bleeding. VWD follows an autosomal dominant inheritance pattern and is classified into three types (1, 2, and 3), each differing in severity. Typical symptoms include excessive bleeding from minor injuries, frequent nosebleeds, prolonged or heavy menstrual periods, and extended bleeding after dental procedures or surgery. Although there is no permanent cure, treatments such as desmopressin and clotting factor replacement therapies can effectively manage symptoms, enabling most individuals to lead normal, active lives.
The specific symptoms can vary depending on the type and severity of the condition but often include easy bruising, recurrent nosebleeds, heavy menstrual bleeding, and prolonged bleeding after injuries or medical procedures. Severe forms, like type 3 VWD, may cause spontaneous bleeding and internal bleeding into joints or soft tissues, resulting in pain and swelling. In many cases, symptoms become apparent only during a bleeding episode. Diagnosis requires a thorough medical history along with specialized blood tests that assess VWF levels, VWF activity, and factor VIII activity to determine the type and extent of the disorder.
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“Von Willebrand Disease Pipeline Insight 2024” report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Von Willebrand Disease Therapeutics Market.
Key Takeaways from the Von Willebrand Disease Pipeline Report
DelveInsight’s Von Willebrand Disease pipeline report depicts a robust space with 20+ active players working to develop 22+ pipeline therapies for Von Willebrand Disease treatment.
In December 2023, the US Food and Drug Administration (FDA) granted expanded approval to WILATE, making it the first VWF concentrate approved for prophylaxis in all types of von Willebrand disease.
In May 2023, the FDA also granted Orphan Drug Designation to VGA039 for the treatment of von Willebrand disease, a rare bleeding disorder.
The dynamics of the von Willebrand disease market are expected to shift in the coming years due to the expanded use of VONVENDI (BAX 111) for both prophylactic and pediatric treatments in the US. Its expanded approval by the FDA in April 2018 for perioperative bleeding management in adults is likely to increase awareness among von Willebrand disease patients with VWF defects, particularly those with moderate disease who are currently undertreated.
Key Von Willebrand Disease companies such as Vega Therapeutics, Hemab, and others are evaluating new drugs for Von Willebrand Disease to improve the treatment landscape.
Promising Von Willebrand Disease pipeline therapies in various stages of development include BT200, and others.
Von Willebrand Disease Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Von Willebrand Disease Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Von Willebrand Disease treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Von Willebrand Disease market.
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Von Willebrand’s Disease Emerging Drugs
BT200: Band Therapeutics
Von Willebrand Disease Companies
More than three major companies are actively developing treatments for Von Willebrand Disease. Among these, Band Therapeutics has the most advanced drug candidates, currently in Phase II of clinical trials.
DelveInsight’s report covers around 22+ products under different phases of clinical development like
Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates
Von Willebrand Disease pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
Intravenous
Subcutaneous
Oral
Intramuscular
Von Willebrand Disease Products have been categorized under various Molecule types such as
Monoclonal antibody
Small molecule
Peptide
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Von Willebrand Disease Pipeline Therapeutic Assessment
• Von Willebrand Disease Assessment by Product Type
• Von Willebrand Disease By Stage
• Von Willebrand Disease Assessment by Route of Administration
• Von Willebrand Disease Assessment by Molecule Type
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Table of Content
1. Report Introduction
2. Executive Summary
3. Von Willebrand Disease Current Treatment Patterns
4. Von Willebrand Disease – DelveInsight’s Analytical Perspective
5. Therapeutic Assessment
6. Von Willebrand Disease Late-Stage Products (Phase-III)
7. Von Willebrand Disease Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Von Willebrand Disease Discontinued Products
13. Von Willebrand Disease Product Profiles
14. Von Willebrand Disease Key Companies
15. Von Willebrand Disease Key Products
16. Dormant and Discontinued Products
17. Von Willebrand Disease Unmet Needs
18. Von Willebrand Disease Future Perspectives
19. Von Willebrand Disease Analyst Review
20. Appendix
21. Report Methodology
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